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Ruxolitinib targets JAK1/JAK2 (with moderate inhibition of TYK2) [393] and is approved for true erythrocytosis and intermediate- to high-risk primary myelofibrosis [394, 395] and showed potential to improve ACR response and HAQ-DI in a phase IIa trial in RA [396]

Metformin inhibits Melanoma development through autophagy and apoptosis mechanisms

On the other hand, Tfh cells play a protective role in the humoral immunity stimulated by vaccination (95, 96)

It also plays a crucial role in recycling other antioxidants like vitamins C and E, maintaining immune balance, and promoting healthy aging by reducing the impact of environmental and metabolic stressors on the body

L-Ascorbic Acid Vitamin C enhances collagen production, supports skin elasticity, and boosts the antioxidant effect of glutathione